Microcalorimetric study of the toxic effect of sodium selenite on the mitochondria metabolism of Carassius auratus liver |
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| Authors: | Xi Li Yi Liu Fengjiao Deng Cunxin Wang Songsheng Qu |
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| Institution: | (1) Department of Chemistry, Wuhan University, Wuhan, People’s Republic of China;(2) School of Life Science, Wuhan University, Wuhan, People’s Republic of China;(3) School of Material Science and Engineering, Wuhan University of Technology, Wuhan, People’s Republic of China |
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| Abstract: | The fundamental thermogenesis curves of the metabolic process of liver mitochondria from Carassius auratus and the toxic effect of Na2SeO3 on it were studied by using an LKB-2277 bioactivity monitor, ampoule method, at 28°C. From the thermogenesis curves, the
thermokinetic equations were established under different conditions. The kinetics show that a low concentration of Na2SeO3 (1–4 mg/L) had promoting action on the metabolism process of Carassius auratus liver mitochondria, but that a high concentration of Na2SeO3 (8–16 mg/L) inhibited the mitochondria metabolism. |
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| Keywords: | Liver mitochondria metabolism Na2SeO3 toxicity microcalorimetry |
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