The cell cycle associated protein, HTm4, is expressed in differentiating cellsof the hematopoietic and central nervous system in mice |
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| Authors: | Jeffery L Kutok Xing Yang Rebecca D Folkerth Jaime Imitola Khadir Raddassi Yoshihiko Yano Saira Salahuddin Joel Lawitts Hans Imboden Masanobu Chinami Taro Shirakawa Helen Turner Samia Khoury Mohamed H Sayegh David Scadden Chaker Adra |
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| Institution: | (1) Department of Pathology, Brigham and Women,s Hospital, Harvard Medical School, Boston, MA 02115, USA;(2) Department of Medicine, Division of Hematology/Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA;(3) Center For Neurological Diseases, Brigham and Women,s Hospital, Department of Neurology, Harvard Medical School, Boston, MA 02115, USA;(4) Division of Neurobiology, University of Bern, Baltzerstrasse 4, CH, 3012 Bern, Switzerland;(5) Department of Nutrition, Kyushu Women,s University, Jiyugaoka 1-1, kitakyushushi 807-8586, Japan;(6) Department of Health Promotion & Human Behavior, Kyoto University Graduate School of Public Health, Kyoto, 606-8501 Japan;(7) RIKEN SNP Typing Center, Shirokanedai 4-6-1, Tokyo 108-8639, Japan;(8) Laboratory of Cell Biology and Immunology, The Queens Medical Center, Honolulu, HI;(9) Laboratory of Immunogenetics & Transplantation, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA;(10) Department of Medicine, Children Hospital, Harvard Medical School, Boston, MA 02115, USA;(11) Experimental Hematology, AIDS Research Center, Massachusetts General Hospital, Boston, MA 02129, USA |
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| Abstract: | HTm4 is a member of a newly defined family of human and murine proteins, the MS4 (membrane-spanning four) protein group, which has a distinctive four-transmembrane structure. MS4 protein functions include roles as cell surface signaling receptors and intracellular adapter proteins. We have previously demonstrated that HTm4 regulates the function of the KAP phosphatase, a key regulator of cell cycle progression. In humans, the expression of HTm4 is largely restricted to cells of the hematopoietic lineage, possibly reflecting a causal role for this molecule in differentiation/proliferation of hematopoietic lineage cells. In this study, we show that, like the human homologue, murine HTm4 is also predominantly a hematopoietic protein with distinctive expression patterns in developing murine embryos and in adult animals. In addition, we observed that murine HTm4 is highly expressed in the developing and adult murine nervous system, suggesting a previously unrecognized role in central and peripheral nervous system development.JLK and XY contributed equally to this work |
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