| 血管紧张素II2型受体基因缺失不影响肾素—血管紧张素系统 |
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| 引用本文： | Li WG,Chen XM,Ye YZ,Zhang Y,Yu LF. 血管紧张素II2型受体基因缺失不影响肾素—血管紧张素系统[J]. 生理学报, 1998, 50(4): 460-464 |
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| 作者姓名： | Li WG Chen XM Ye YZ Zhang Y Yu LF |
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| 作者单位： | 解放军总医院肾科!解放军肾病中心暨重点实验室,北京,100853,解放军总医院肾科!解放军肾病中心暨重点实验室,北京,100853,解放军总医院肾科!解放军肾病中心暨重点实验室,北京,100853,解放军总医院肾科!解放军肾病中心暨重点实验室,北京,100853,解放军总医院肾科!解放军肾病 |
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| 摘 要： | 基于目前对血管紧张素Ⅱ２型受体（ＡＴ２）功能的认识,认为血管紧张素Ⅱ１型受体（ＡＴ１）和ＡＴ２受体有相互拮抗作用。依据上述论点,本研究利用ＡＴ２受体基因敲出小鼠,观察了ＡＴ２受体缺失后是否造成肾素－血管紧张素系统其它成分代偿性紊乱。结果发现,ＡＴ２受体基因缺失小鼠血浆和肾组织中血管紧张素Ⅱ的浓度以及肾组织中肾素、ＡＴ１Ａ受体的基因表达均未发生明显改变,表明ＡＴ２受体缺失未对肾素－血管紧张素系统产生
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| 关 键 词： | AT2受体 基因缺失 肾素 血管紧张素 |
| 修稿时间： | 1997-08-22 |
Angiotensin II type 2 receptor gene deletion does not affect renin-angiotensin system |
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| Li W G,Chen X M,Ye Y Z,Zhang Y,Yu L F. Angiotensin II type 2 receptor gene deletion does not affect renin-angiotensin system[J]. Acta Physiologica Sinica, 1998, 50(4): 460-464 |
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| Authors: | Li W G Chen X M Ye Y Z Zhang Y Yu L F |
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| Affiliation: | Division of Nephrology, General Hospital of PLA, Center of Nephrology and Key Laboratory of PLA, Beijing 100853. |
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| Abstract: | It has been postulated that Angiotensin II type 2 receptor (AT2) functionally antagonizes type 1 (AT1) receptor. In the present study, we investigated whether gene deletion of AT2 receptor causes the compensatory chaos of renin-angiotensin system in mice. It was shown that the concentrations of Angiotensin II in plasma and kidney tissues and the expressions of renin and AT1A receptor in the AT2 gene null mice were unchanged, as compared with those in AT2 wild-type mice. This result suggests that gene deletion of AT2 receptor does not markedly impact the stability of renin-angiotensin system and the inductive function of AT2 receptor is compensated in a way remaining to be clarified. |
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| Keywords: | AT2 receptor gene deletion renin-angiotensin system |
| 本文献已被 CNKI 维普 PubMed 等数据库收录！ |
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