Ellagic acid derivatives and cytotoxic cucurbitacins from Elaeocarpus mastersii |
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| Authors: | Ito Aiko Chai Hee-Byung Lee Dongho Kardono Leonardus B S Riswan Soedarsono Farnsworth Norman R Cordell Geoffrey A Pezzuto John M Kinghorn A Douglas |
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| Affiliation: | Program for Collaborative Research in the Pharmaceutical Sciences and Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, IL 60612, USA. |
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| Abstract: | Bioassay-guided investigation of the bark of Elaeocarpus mastersii using KB (human oral epidermoid carcinoma) cells as a monitor led to the isolation of two cucurbitacins, cucurbitacin D and cucurbitacin F as cytotoxic principles, together with two ellagic acid derivatives, 4'-O-methylellagic acid 3-(2",3"-di-O-acetyl)-alpha-L-rhamnoside (1) and 4,4'-O-dimethylellagic acid 3-(2",3"-di-O-acetyl)-alpha-L-rhamnoside (2). These compounds were evaluated against a panel of human tumor cell lines. |
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| Keywords: | Elaeocarpus mastersii Elaeocarpaceae Cytotoxicity Ellagic acid derivatives Cucurbitacins |
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