Synthesis and evaluation of metallocene containing methylidene-1,3-dihydro-2H-indol-2-ones as kinase inhibitors |
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| Authors: | Spencer John Amin Jahangir Callear Samantha K Tizzard Graham J Coles Simon J Coxhead Peter Guille Matthew |
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| Affiliation: | School of Science, University of Greenwich at Medway, Central Avenue, Chatham, Kent, ME4 4TB, UK. j.spencer@gre.ac.uk |
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| Abstract: | (E)- and (Z)-3-Ferrocenylmethylidene-1,3-dihydro-2H-indol-2-ones 1 have been structurally modified in order to explore SAR against a range of kinases. Of note is the submicromolar to low micromolar inhibition of DYRK3 and 4 by a number of complexes. Screening using Xenopus embryos showed some of the compounds to have potent antiangiogenisis activity. |
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