| 一种抗AIV共有独特型抗体具有AIV血凝素分子的内影象 |
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| 引用本文： | 李宝全,彭军,牛钟相,姜世金.一种抗AIV共有独特型抗体具有AIV血凝素分子的内影象[J].Virologica Sinica,2004,19(6):624-626. |
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| 作者姓名： | 李宝全 彭军 牛钟相 姜世金 |
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| 作者单位： | 山东农业大学动物科技学院 山东泰安271018
(李宝全，彭军，牛钟相)，山东农业大学动物科技学院 山东泰安271018(姜世金) |
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| 摘 要： | 用纯化的鸡抗禽流感病毒(AIV)IgG作免疫原，通过单克隆抗体技术制备出1株分泌针对鸡抗AIV和兔抗AIV共有独特型抗体的杂交瘤细胞。竞争抑制试验、特异性检验和诱导产生血凝抑制抗体的功能实验证明，此抗体具有AIV血凝素分子的内影象。
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| 关 键 词： | 禽流感病毒 抗独特型抗体 共有独特型 |
An Anti-species-sharing-idiotypic Antibody to AIV Bearing the Internal Image of Hemagglutinin on AIV |
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| LI Bao-quan,PENG Jun,NIU Zhong-xiang,JIANG Shi-jin.An Anti-species-sharing-idiotypic Antibody to AIV Bearing the Internal Image of Hemagglutinin on AIV[J].中国病毒学(英文版),2004,19(6):624-626. |
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| Authors: | LI Bao-quan PENG Jun NIU Zhong-xiang JIANG Shi-jin |
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| Institution: | LI Bao-quan,PENG Jun,NIU Zhong-xiang**,JIANG Shi-jin |
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| Abstract: | One anti-idiotypic monoclonal antibody(a-Id Mab)was raised directed to both rabbit and chicken IgG against Avian influenza virus(AIV). The Mab was able to inhibit the binding of AIV to anti-AIV IgG and specific in binding anti-H9-subtype-AIV IgG. Another experiment demonstrated that the Mab might induce chicken to generate hemagglutination inhibition antibodies. These results indicated this anti-species-sharing-idiotypic antibody bore the internal image of hemagglutinin on AIV. |
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| Keywords: | AIV Anti-idiotypic antibody Sharing idiotype |
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