Quantitative 177Lu SPECT imaging using advanced correction algorithms in non-reference geometry |
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| Institution: | 1. ENEA, National Institute of Ionizing Radiation Metrology, Via Anguillarese 301, 00123 Rome, Italy;2. Department of Human Anatomy, Histology, Forensic Medicine and Orthopedics, Sapienza University of Rome, Via Borelli 50, 00161 Rome, Italy;3. Laboratory of Medical Physics and Expert Systems, Regina Elena National Cancer Institute, Via Elio Chianesi 53, 00044 Rome, Italy;4. ABX-CRO Advanced Pharmaceutical Services, Forschungsgesellschaft m.b.H. Blasewitzer Straße 78-80 D, 01307 Dresden, Germany;5. Medical Physics Section, Department of Biopathology and Imaging, Tor Vergata University, Via Montpellier 1, 00133 Rome, Italy;1. Department of Radiation Oncology, Medical Faculty and University Hospital Carl Gustav Carus, Technische Universität Dresden, Germany;2. OncoRay-National Center for Radiation Research in Oncology, Medical Faculty and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden-Rossendorf, Germany;3. Institute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden – Rossendorf, Germany;4. Institute of Radiation Oncology, Helmholtz-Zentrum Dresden – Rossendorf, Germany;5. Department of Chemistry and Food Chemistry, Technische Universität Dresden, Germany;6. German Cancer Consortium (DKTK), Partner Site Dresden and German Cancer Research Center (DKFZ), Heidelberg, Germany;7. Department of Radiation Oncology, University Hospital, Eberhard Karls Universität Tübingen, Germany;1. Department of Radiology, University of Tennessee Graduate School of Medicine, Knoxville, TN 37920;2. Molecular Imaging and Translational Research Program, University of Tennessee Graduate School of Medicine, Knoxville, TN 37920;3. Department of Radiology, University of Tennessee Medical Center, 1924 Alcoa Highway, Knoxville, TN 37920;1. Medical Imaging Research Group, University of British Columbia, Vancouver, British Columbia, Canada;2. Department of Physics and Astronomy, University of British Columbia, Vancouver, British Columbia, Canada;3. Vancouver Coastal Health Authority, Vancouver, British Columbia, Canada;1. Medical Physics Department, AO Ordine Mauriziano, Turin, Italy;2. Gastroenterology Department, AO Ordine Mauriziano, Turin, Italy;3. Energy Department, Politecnico di Torino, Italy;4. Medical Physics Department, AOU Policlinico Umberto I, Rome, Italy;5. Nuclear Medicine Department, AO Ordine Mauriziano, Turin, Italy;1. Clinic of Nuclear Medicine, University Hospital Erlangen, 91054 Erlangen, Germany;2. CIML Group, Biophysics, University of Regensburg, 93040 Regensburg, Germany;3. Pattern Recognition Lab, University of Erlangen-Nürnberg, 91058 Erlangen, Germany;1. Department of Radiation Oncology, University of Michigan, Ann Arbor, Michigan;2. Department of Radiology, University of Michigan Medical School, Ann Arbor, Michigan |
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| Abstract: | Peptide receptor therapy with 177Lu-labelled somatostatin analogues is a promising tool in the management of patients with inoperable or metastasized neuroendocrine tumours. The aim of this work was to perform accurate activity quantification of 177Lu in complex anthropomorphic geometry using advanced correction algorithms.Acquisitions were performed on the higher 177Lu photopeak (208 keV) using a Philips IRIX gamma camera provided with medium-energy collimators. System calibration was performed using a 16 mL Jaszczak sphere surrounded by non-radioactive water. Attenuation correction was performed using μ-maps derived from CT data, while scatter and septal penetration corrections were performed using the transmission-dependent convolution-subtraction method. SPECT acquisitions were finally corrected for dead time and partial volume effects. Image analysis was performed using the commercial QSPECT software.The quantitative SPECT approach was validated on an anthropomorphic phantom provided with a home-made insert simulating a hepatic lesion. Quantitative accuracy was studied using three tumour-to-background activity concentration ratios (6:1, 9:1, 14:1).For all acquisitions, the recovered total activity was within 12% of the calibrated activity both in the background region and in the tumour. Using a 6:1 tumour-to-background ratio the recovered total activity was within 2% in the tumour and within 5% in the background. Partial volume effects, if not properly accounted for, can lead to significant activity underestimations in clinical conditions.In conclusion, accurate activity quantification of 177Lu can be obtained if activity measurements are performed with equipment traceable to primary standards, advanced correction algorithms are used and acquisitions are performed at the 208 keV photopeak using medium-energy collimators. |
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| Keywords: | Quantitative imaging Correction algorithms Transmission-dependent convolution-subtraction correction algorithm |
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