PET guidance in prostate cancer radiotherapy: Quantitative imaging to predict response and guide treatment |
| |
| Affiliation: | 1. Medical Physics Unit, San Raffaele Scientific Institute, Via Olgettina 60, 20132 Milan, Italy;2. Nuclear Medicine Unit, San Raffaele Scientific Institute, Via Olgettina 60, Milan, Italy;1. Institut de Radiophysique, Lausanne, Switzerland;2. Laboratoire National Henri Becquerel, Gif sur Yvette Cedex, France;1. Neurosurgery Department, Hospital Universitari de Bellvitge, Feixa Llarga s/n, 08907 Hospitalet de Llobregat, Barcelona, Spain;2. Infectious Diseases Department, Hospital Universitari de Bellvitge, Hospitalet de Llobregat, Barcelona, Spain;3. Neurosurgery Department, Greater Manchester Neuroscience Centre, Salford Royal Foundation Trust, Stott Lane, Salford, UK;4. Microbiology Department, Hospital Universitari de Bellvitge, Hospitalet de Llobregat, Barcelona, Spain;1. Scientific Comm, Global Med Comm – Bio-Medicines BU-NS, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285, USA;2. Department of Neurology, Keck School of Medicine at the University of Southern California, 1520 San Pablo Street, HCC-2, Suite 3000, Los Angeles, CA 90033, USA;3. Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285, USA |
| |
| Abstract: | Positron emission tomography (PET) allows a monitoring and recording of the spatial and temporal distribution of molecular/cellular processes for diagnostic and therapeutic applications.The aim of this review is to describe the current applications and to explore the role of PET in prostate cancer management, mainly in the radiation therapy (RT) scenario.The state-of-the art of PET for prostate cancer will be presented together with the impact of new specific PET tracers and technological developments aiming at obtaining better imaging quality, increased tumor detectability and more accurate volume delineation.An increased number of studies have been focusing on PET quantification methods as predictive biomarkers capable of guiding individualized treatment and improving patient outcome; the sophisticated advanced intensity modulated and imaged guided radiation therapy techniques (IMRT/IGRT) are capable of boosting more radioresistant tumor (sub)volumes.The use of advanced feature analyses of PET images is an approach that holds great promise with regard to several oncological diseases, but needs further validation in managing prostate diseases. |
| |
| Keywords: | Pet Prostate cancer Predicting biomarkers Individualized treatment |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
