Imaging performance of phase-contrast breast computed tomography with synchrotron radiation and a CdTe photon-counting detector |
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| Institution: | 1. Universita’ di Napoli Federico II, Dipartimento di Fisica “Ettore Pancini”, and INFN Sezione di Napoli, Napoli, Italy;2. Universita’ di Sassari, Sassari, Italy;3. INFN Sezione di Cagliari, Cagliari, Italy;4. INFN Sezione di Pisa, Pisa, Italy;5. Universita’ di Trieste, Dipartimento di Fisica, and INFN Sezione di Trieste, Trieste, Italy;1. Key Laboratory for Precision and Non-Traditional Machining Technology of Ministry of Education, Dalian University of Technology, Dalian 116024, People’s Republic of China;2. School of Materials Science and Engineering, Dalian University of Technology, Dalian 116024, People’s Republic of China;3. State Key Laboratory of Metastable Materials Science and Technology, Yanshan University, Qinhuangdao 066004, People’s Republic of China;1. College of Aerospace Engineering, Chongqing University, Chongqing 400044, China;2. State Key Laboratory of Coal Mine Disaster Dynamics and Control, Chongqing University, Chongqing 400044, China;3. State Key Laboratory of Structural Analysis for Industrial Equipment, Department of Engineering Mechanics, Faculty of Vehicle Engineering and Mechanics, Dalian University of Technology, Dalian 116023, China;1. Department of Radiological Science, Eulji University, 553, Sanseong-daero, Sujeong-gu, Seongnam-si, Gyeonggi-do, Republic of Korea;2. Department of Mathematics and Statistics, McGill University, Canada;3. Department of Radiological Science and Radiation Convergence Engineering, Yonsei University, Republic of Korea;1. A. O. Ordine Mauriziano di Torino, Medical Physics Department, Torino, Italy;2. University of Naples Federico II, Dept. of Physics “Ettore Pancini” and INFN Division of Naples, Napoli, Italy;1. Department of Radiology, Shanghai Tenth People''s Hospital, Tongji University, Shanghai 200072, China;2. Department of Electrical and Computer Engineering, University of Rochester, Rochester, NY 14627, USA;3. Department of Imaging Sciences, University of Rochester Medical Center, Rochester, NY 14642, USA;4. Koning Corporation, West Henrietta, NY 14586, USA;5. Department of Imaging Sciences, University of Rochester Medical Center, Rochester, NY 14642, USA;1. Department of Biomedical Engineering, University of Rochester Medical Center, Rochester, NY, USA;2. Department of Imaging Sciences, University of Rochester Medical Center, Rochester, NY, USA;3. Department of Electrical Engineering, University of Rochester Medical Center, Rochester, NY, USA;4. Department of Radiological Sciences, University of California Los Angeles, Los Angeles, USA;5. European Synchrotron Radiation Facility, Grenoble, France;6. Faculty of Medicine and Institute of Clinical Radiology, Ludwig Maximilians University, Munich Germany |
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| Abstract: | PurposeWithin the SYRMA-CT collaboration based at the ELETTRA synchrotron radiation (SR) facility the authors investigated the imaging performance of the phase-contrast computed tomography (CT) system dedicated to monochromatic in vivo 3D imaging of the female breast, for breast cancer diagnosis.MethodsTest objects were imaged at 38 keV using monochromatic SR and a high-resolution CdTe photon-counting detector. Signal and noise performance were evaluated using modulation transfer function (MTF) and noise power spectrum. The analysis was performed on the images obtained with the application of a phase retrieval algorithm as well as on those obtained without phase retrieval. The contrast to noise ratio (CNR) and the capability of detecting test microcalcification clusters and soft masses were investigated.ResultsFor a voxel size of (60 μm)3, images without phase retrieval showed higher spatial resolution (6.7 mm−1 at 10% MTF) than corresponding images with phase retrieval (2.5 mm−1). Phase retrieval produced a reduction of the noise level and an increase of the CNR by more than one order of magnitude, compared to raw phase-contrast images. Microcalcifications with a diameter down to 130 μm could be detected in both types of images.ConclusionsThe investigation on test objects indicates that breast CT with a monochromatic SR source is technically feasible in terms of spatial resolution, image noise and contrast, for in vivo 3D imaging with a dose comparable to that of two-view mammography. Images obtained with the phase retrieval algorithm showed the best performance in the trade-off between spatial resolution and image noise. |
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| Keywords: | Synchrotron radiation Breast cancer Photon-counting detector Computed tomography Phase-contrast imaging |
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