In vivo skin dose measurement using MOSkin detectors in tangential breast radiotherapy |
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| Institution: | 1. Clinical Oncology Unit, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia;2. Department of Biomedical Imaging, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia;3. University of Malaya Research Imaging Centre, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia;4. Centre for Medical Radiation Physics, University of Wollongong, Wollongong, Australia;1. Illawarra Cancer Care Centre, Wollongong, Australia;2. Centre for Medical Radiation Physics, University of Wollongong, Australia;3. Northern Sydney Cancer Centre, St Leonards, Australia;4. Peter MacCallum Cancer Centre, Melbourne, Australia;5. Ingham Institute for Applied Medical Research, Liverpool, Australia;6. Sydney Medical School, University of Sydney, Australia;1. Clinic for Radiooncology, University of Saarland, Homburg, 66421, Germany;2. University of Nis, Faculty of Electronic Engineering, Aleksandra Medvedeva 14, 18000, Nis, Serbia;3. Vinca Institute of Nuclear Science, University of Belgrade, PO Box 522, 11001, Belgrade, Serbia;1. CEA, LIST, LNE/LNHB, 91191 Gif-sur-Yvette, France;2. Radioprotection, Dosimetry and Calibration, Belgian Nuclear Research Institute, Mol, Belgium;3. CEA, LIST, DCSI, 91191 Gif-sur-Yvette, France;4. Universitat Autònoma de Barcelona (UAB), Spain;5. Department of Mechanical, Nuclear and Production Engineering, University of Pisa, Italy;6. Ruđer Bošković Institute, Bijenička 54, 10000 Zagreb, Croatia;7. Institute of Nuclear Physics, Krakow, Poland;1. Department of Physics, Università degli Studi di Milano and INFN, Milan, Italy;2. Medical Physics Unit, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy;3. Centre for Medical Radiation Physics, University of Wollongong, Wollongong, NSW, Australia;1. Dipartimento di Scienze Biomediche, Sperimentali e Cliniche, Università degli Studi di Firenze, Italy;2. Azienda Ospedaliero Universitaria Careggi, Firenze, Italy;3. INFN-Dipartimento di Ingegneria Industriale, Università di Roma “Tor Vergata”, Roma, Italy;1. Medical Physics Unit, Dept. of Diagnostic Imaging and Radiotherapy, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy;2. Prostate Cancer Program, Scientific Director’s Office, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy;3. Radiation Oncology 2 Unit, Dept. of Diagnostic Imaging and Radiotherapy, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy;4. Centre for Medical Radiation Physics, University of Wollongong, Australia;5. National Institute of Nuclear Physics INFN, Milan, Italy |
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| Abstract: | The purpose of this study is to measure patient skin dose in tangential breast radiotherapy. Treatment planning dose calculation algorithm such as Pencil Beam Convolution (PBC) and in vivo dosimetry techniques such as radiochromic film can be used to accurately monitor radiation doses at tissue depths, but they are inaccurate for skin dose measurement. A MOSFET-based (MOSkin) detector was used to measure skin dose in this study. Tangential breast radiotherapies (“bolus” and “no bolus”) were simulated on an anthropomorphic phantom and the skin doses were measured. Skin doses were also measured in 13 patients undergoing each of the techniques. In the patient study, the EBT2 measurements and PBC calculation tended to over-estimate the skin dose compared with the MOSkin detector (p < 0.05) in the “no bolus radiotherapy”. No significant differences were observed in the “bolus radiotherapy” (p > 0.05). The results from patients were similar to that of the phantom study. This shows that the EBT2 measurement and PBC calculation, while able to predict accurate doses at tissue depths, are inaccurate in predicting doses at build-up regions. The clinical application of the MOSkin detectors showed that the average total skin doses received by patients were 1662 ± 129 cGy (medial) and 1893 ± 199 cGy (lateral) during “no bolus radiotherapy”. The average total skin doses were 4030 ± 72 cGy (medial) and 4004 ± 91 cGy (lateral) for “bolus radiotherapy”. In some cases, patient skin doses were shown to exceed the dose toxicity level for skin erythema. Hence, a suitable device for in vivo dosimetry is necessary to accurately determine skin dose. |
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| Keywords: | MOSFET Breast conserving radiotherapy Chest wall irradiation Surface dose Superficial dose |
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