Study of the effect of ceramic Ta2O5 nanoparticle distribution on cellular dose enhancement in a kilovoltage photon field |
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| Institution: | 1. Centre for Medical Radiation Physics (CMRP), University of Wollongong, NSW, Australia;2. Illawarra Health and Medical Research Institute (IHMRI), University of Wollongong, NSW, Australia;3. Centre for Medical and Molecular Bioscience, University of Wollongong, NSW, Australia;4. Institute for Superconducting and Electronic Materials, University of Wollongong, NSW, Australia;5. Radiation Oncology Department, Prince of Wales Hospital, Randwick, NSW, Australia;6. CNRS/IN2P3, Centre d’Etudes Nucléaires de Bordeaux-Gradignan, UMR-5797, chemin du solarium, 33175 Gradignan, France;7. Université Bordeaux, Centre d’Etudes Nucléaires de Bordeaux-Gradignan, UMR-5797, chemin du solarium, 33175 Gradignan, France;2. Northern Clinical School, University of Sydney, Camperdown, New South Wales, Australia;3. McCloud Consulting Group, New South Wales, Australia;1. CICESE, División de Física Aplicada, Departamento de Óptica, Carretera Ensenada-Tijuana, No. 3918, Fraccionamiento Zona Playitas, Ensenada, B.C. C.P. 22860, Mexico;2. UABC, Facultad de Ciencias, Km. 103, Carretera Tijuana-Ensenada, Ensenada, B.C. C.P. 22860, Mexico;1. Division of Radiation Oncology, Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX;2. Division of Radiation Oncology, Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, TX;1. Department of Radiation Oncology, University Hospital Zurich and University of Zurich, Switzerland;2. Product Development Group Zurich, Department of Mechanical and Process Engineering, ETH Zurich, Switzerland;1. Resident, Department of Oral and Maxillofacial Surgery, School and Hospital of Stomatology, Wuhan University; Stomatology and Key Laboratory of Oral Biomedicine, Ministry of Education, Department of Oral and Maxillofacial Surgery, School and Hospital of Stomatology, Wuhan University, Wuhan, Hubei, China; Department of Oral and Maxillofacial Surgery, The First People''s Hospital of Foshan, Foshan, Guangdong, China;2. Resident, Department of Oral and Maxillofacial Surgery, School and Hospital of Stomatology, Wuhan University; Stomatology and Key Laboratory of Oral Biomedicine, Ministry of Education, Department of Oral and Maxillofacial Surgery, School and Hospital of Stomatology, Wuhan University, Wuhan, Hubei, China;3. Professor, Department of Oral and Maxillofacial Surgery, The First People''s Hospital of Foshan, Foshan, Guangdong, China;4. Professor, Department of Oral and Maxillofacial Surgery, School and Hospital of Stomatology, Wuhan University; Stomatology and Key Laboratory of Oral Biomedicine, Ministry of Education, Department of Oral and Maxillofacial Surgery, School and Hospital of Stomatology, Wuhan University, Wuhan, Hubei, China |
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| Abstract: | The application of nanoparticles (NPs) in radiotherapy is an increasingly attractive technique to improve clinical outcomes. The internalisation of NPs within the tumour cells enables an increased radiation dose to critical cellular structures. The purpose of this study is to investigate, by means of Geant4 simulations, the dose enhancement within a cell population irradiated with a 150 kVp photon field in the presence of a varying concentration of tantalum pentoxide (Ta2O5) NP aggregates, experimentally observed to form shells within tumour cells. This scenario is compared to the more traditionally simulated homogeneous solution of NP material in water with the same weight fraction of Ta2O5, as well as to a cell population without NPs present. The production of secondary electrons is enhanced by increased photoelectric effect interactions within the high-Z material and this is examined in terms of their kinetic energy spectra and linear energy transfer (LET) with various NP distributions compared to water. Our results indicate that the shell formation scenario limits the dose enhancement at 150 kVp. The underlying mechanism for this limit is discussed. |
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| Keywords: | Ceramic nanoparticles Dose enhancement X-ray radiotherapy Monte Carlo method Geant4 |
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