Spermatid manchette: plugging proteins to zero into the sperm tail |
| |
Authors: | Kierszenbaum A L |
| |
Affiliation: | Department of Cell Biology and Anatomical Sciences, The City University of New York Medical School, 138th Street and Convent Avenue, New York, NY 10031, USA. kier@med.cuny.edu |
| |
Abstract: | Spermiogenesis pursues three major objectives: (1) The safeguard of the male genome within the confines of a compact nucleus. (2) The accumulation of enzymes in the acrosome of be released at fertilization. (3) The development of a sperm propelling tail consisting of an axoneme surrounded by a scaffold of keratin-containing outer dense fibers and a fibrous sheath. Recent experimental data indicate that three keratins-Sak57, 0df1 and 0df2-and other proteins (the 26S proteasome and the 0df1-binding protein Spag4) are temporarily stored in the manchette before being sorted to the developing sperm tail. These findings support a general model for the manchette as an ephemeral structure timely developed and strategically positioned to provide a transient storage to both structural and signaling proteins. Some of the proteins are later sorted to the developing tail; others may participate in the reciprocal nuclear-cytoplasmic signaling pathways as the gene activity of the male genome gradually becomes silent. Mol. Reprod. Dev. 59: 347-349, 2001. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|