Specific inhibition of iturin biosynthesis by cerulenin |
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Authors: | M L Hourdou F Besson G Michel |
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Institution: | Laboratoire de biochimie microbienne, Université Claude Bernard, Lyon I, Villeurbanne, France. |
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Abstract: | Cerulenin, an inhibitor of fatty acid synthesis, inhibits the biosynthesis of iturin by Bacillus subtilis. With a cerulenin concentration of 2 micrograms/mL, 50% inhibition was achieved. At this concentration, cerulenin does not affect growth or total protein synthesis but does inhibit the incorporation of sodium 14C]acetate, 14C]myristic acid, and 14C]asparagine into iturin. Since cerulenin is known to block the condensation of malonyl-CoA subunits in the formation of fatty acids, the inhibition of iturin and beta-amino acid syntheses by cerulenin is discussed in relation with lipid synthesis. |
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