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Bacteroides fragilis Toxin Coordinates a Pro-carcinogenic Inflammatory Cascade via Targeting of Colonic Epithelial Cells
Authors:Liam Chung  Erik Thiele Orberg  Abby L Geis  June L Chan  Kai Fu  Christina E DeStefano Shields  Christine M Dejea  Payam Fathi  Jie Chen  Benjamin B Finard  Ada J Tam  Florencia McAllister  Hongni Fan  Xinqun Wu  Sudipto Ganguly  Andriana Lebid  Paul Metz  Sara W Van Meerbeke  Franck Housseau
Institution:1. Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA;2. Department of Oncology, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, Baltimore, MD 21287, USA;3. Translational Tissue Engineering Center, Wilmer Eye Institute and Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21287, USA;4. Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA;5. Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA;6. Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA;7. Department of Pathology, Radboud University Medical Centre, Geert Grooteplein-Zuid 10, 6525 GA, Nijmegen, Netherlands;8. Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA;9. Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Abstract:
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  • Keywords:mucosal immunology  inflammation  colorectal cancer  STAT-3  Nf-κB  myeloid cells
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