P2 receptor-mediated signaling in mast cell biology |
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Authors: | Elena Bulanova Silvia Bulfone-Paus |
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Institution: | (1) Department of Immunology and Cell Biology, Research Center Borstel, 23845 Borstel, Germany |
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Abstract: | Mast cells are widely recognized as effector cells of allergic inflammatory reactions. They contribute to the pathogenesis
of different chronic inflammatory diseases, wound healing, fibrosis, thrombosis/fibrinolysis, and anti-tumor immune responses.
In this paper, we summarized the role of P2X and P2Y receptors in mast cell activation and effector functions. Mast cells
are an abundant source of ATP which is stored in their granules and secreted upon activation. We discuss the contribution
of mast cells to the extracellular ATP release and to the maintenance of extracellular nucleotides pool. Recent publications
highlight the importance of purinergic signaling for the pathogenesis of chronic airway inflammation. Therefore, the role
of ATP and P2 receptors in allergic inflammation with focus on mast cells was analyzed. Finally, ATP functions as mast cell
autocrine/paracrine factor and as messenger in intercellular communication between mast cells, nerves, and glia in the central
nervous system. |
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