The C. elegans Hox gene ceh-13 regulates cell migration and fusion in a non-colinear way. Implications for the early evolution of Hoxclusters |
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Authors: | Borbála Tihanyi Tibor Vellai Ágnes Regős Eszter Ari Fritz Müller Krisztina Takács-Vellai |
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Affiliation: | 1.Department of Genetics,E?tv?s Loránd University,Budapest,Hungary;2.Department of Biology,University of Fribourg,Fribourg,Switzerland |
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Abstract: | Background Hox genes play a central role in axial patterning during animal development. They are clustered in the genome and specify cell fate in sequential domains along the anteroposterior (A-P) body axis in a conserved order that is co-linear with their relative genomic position. In the soil worm Caenorhabditis elegans, this striking rule of co-linearity is broken by the anterior Hox gene ceh-13, which is located between the two middle Hox paralogs, lin-39 and mab-5, within the loosely organized nematode Hox cluster. Despite its evolutionary and developmental significance, the functional consequence of this unusual genomic organization remains unresolved. |
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