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Loss of PRMT7 reprograms glycine metabolism to selectively eradicate leukemia stem cells in CML
Institution:1. Jinan University Institute of Tumor Pharmacology, College of Pharmacy, Jinan University, Guangzhou 510632, China;2. Department of Hematology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China;3. Department of Hematology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China;4. Department of Hematology, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, China;5. State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, China;6. Key Laboratory for Regenerative Medicine of Ministry of Education, Institute of Hematology, School of Medicine, Jinan University, Guangzhou 510632, China;7. State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China;8. State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060, China
Abstract:
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  • Keywords:chronic myelogenous leukemia  leukemia stem cells  survival  self-renewal  epigenetic  PRMT7  GLDC  glycine metabolism  JS1310
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