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Itaconate and itaconate derivatives target JAK1 to suppress alternative activation of macrophages
Affiliation:1. School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, 152–160 Pearse Street, Dublin D02 R590, Ireland;2. Synthetic and Functional Biomolecules Center, Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, Peking-Tsinghua Center for Life Sciences, Peking University, Beijing 100871, China;3. Drug Discovery Science & Technology, AbbVie Inc., 1 North Waukegon Road, North Chicago, IL 60064, USA;4. AbbVie, Bio Research Center, 100 Research Drive, Worcester, MA 01608, USA;5. Department of Experimental and Clinical Medicine, “Magna Græcia” University of Catanzaro, Catanzaro, Italy;6. School of Medicine, Trinity Biomedical Sciences Institute, Trinity College Dublin, 152–160 Pearse Street, Dublin D02 R590, Ireland;7. Centre for Inflammation, Centenary Institute and University of Technology Sydney, Faculty of Science, School of Life Sciences, Sydney, NSW, Australia;8. Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, Sydney, NSW, Australia;9. School of Life Sciences, Faculty of Science, University of Technology Sydney, Sydney, NSW, Australia;10. Priority Research Centre for Healthy Lungs, Hunter Medical Research Institute and University of Newcastle, Newcastle, NSW, Australia
Abstract:
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  • Keywords:itaconate  macrophages  M2 macrophage  Jak-STAT  immunometabolism  Krebs cycle
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