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Klebsiella pneumoniae induces host metabolic stress that promotes tolerance to pulmonary infection
Affiliation:1. Department of Pediatrics, Columbia University, New York, NY 10032, USA;2. Department of Genetics and Genomic Sciences, Mt. Sinai Icahn School of Medicine, New York, NY 10029, USA;3. Department of Microbiology and Immunology, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia;4. Department of Microbial Pathogenesis, University of Maryland, Baltimore, MD 21201, USA;5. Department of Medicine, Columbia University, New York, NY 10032, USA;6. Department of Biological Sciences, University of Calgary, Calgary, T2N 1N4, Canada;7. Microbiome & Pathogen Genomics Collaborative Center, Columbia University, New York, NY 10032, USA;8. Department of Chemistry, Columbia University, New York, NY 10027, USA;9. Department of Biological Sciences, Columbia University, New York, NY 10027, USA;10. Department of Pathology and Cell Biology, Columbia University, New York, NY 10032, USA;11. Microbiological Diagnostic Unit Public Health Laboratory, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia;12. Sema4: A Mount Sinai Venture, Stamford, CT 06902, USA
Abstract:
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  • Keywords:immunometabolism  immunosuppression  MDSCs  M2 macrophages  itaconate  disease tolerance  bacterial adaptation  type 6 secretion system  pulmonary infection
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