6-Hydroxy-1,3-dioxin-4-ones as non-peptidic HIV protease inhibitors |
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| Authors: | Lee Y S Lee Y S Lee J Y Kim S N Lee C K Park H |
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| Affiliation: | Division of Life Sciences, Korea Institute of Science & Technology, Cheongryang, Seoul, South Korea. |
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| Abstract: | HIV protease inhibitors containing 6-hydroxy-1,3-dioxin-4-one ring system as a new scaffold have been prepared. Among them, compound 4d showed potent HIV protease inhibitory activity (IC50 = 0.01 microM) and antiviral activity in cell culture (EC50 = 0.96 microM, SI = 65.69). |
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