赤霉病麦中毒研究Ⅲ．赤霉病麦粗毒素的生殖毒理学研究

赤霉病麦粗毒素为赤霉病麦的乙醇提取物,其中脱氧雪腐镰刀菌烯醇和玉米赤霉烯酮含量分别为11100 ppm和605ppm。家猫和鸽子的致吐剂量分别为300和400 mg粗毒素/kg体重。成年雌雄大鼠经口LD_(50)分别为8150和10550mg粗毒素/kg体重。1000mg粗毒素/kg体重经口给予未成年雌性大鼠,未见有雌激素亢进反应。将粗毒素含量0.01,0.1和0.5％的饲料喂养断奶Wistar大鼠210—301天,在此期间大鼠繁殖F1a和F1b两代仔鼠,并观察至断奶。在所有剂量组均观察到对生长、发育或生殖的程度不同地损害。本文讨论了赤霉病麦对大鼠生殖力的影响及其作用机制。

MYCO TOXICOSIS FROM SCABBY WHEAT INFECTED BY FUSARIUM GRAMINEARIUM III. REPRODUCTION STUDY OF CRUDE TOXIN OF SCABBY WHEAT IN RATS

The crude toxin of scabby wheat contained deoxynivalanol 11100 ppm and zearalenonel 605 ppm. The vomiting doses in pigeon and cat were 300 and 400 mg/ kg body weight respectively. LD_(50) in female and male adult rats were 8150 and 10550 mg/kg body weight respectively. The hyperestrogenemia was not observed after premature female rats were administered the crude toxin 1000mg/kg body weight. Wistar weanling rats were administered the feed contained the crude toxin 0%, 0.01%, 0.1% and 0.5% for 210—301 days. During the period the rats mated twice and Fla and Flb offsprings were observed until their weanling. The damages to the growth, the development and the fertility of the rats and their offsprings were observed in 0.01%, 0.1% and 0.5% groups.