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Design of phosphonium ionic liquids for lipase-catalyzed transesterification |
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| Authors: | Yoshikazu Abe Keisuke Kude Shuichi Hayase Motoi Kawatsura Katsuhiko Tsunashima Toshiyuki Itoh |
| Institution: | aDepartment Materials Science, Faculty of Engineering, Tottori University, Tottori 680-8552, Japan bNippon Chemical Industrial Co., Ltd., 9-11-1 Kameido, Koto-ku, Tokyo 136-8515, Japan |
| Abstract: | Ionic liquids are now recognized as solvents for use in lipase-catalyzed reactions; however, there still remains a serious drawback in that the rate of reaction in an ionic liquid is slower than that in a conventional organic solvent. To overcome this problem, attempts have been made to evolve phosphonium ionic liquids appropriate for lipase-catalyzed reaction; several types of phosphonium salts have been prepared and their capability evaluated for use as solvent for the lipase-catalyzed reaction. Very rapid lipase PS-catalyzed transesterification of secondary alcohols was obtained when 2-methoxyethyl(tri-n-butyl)phosphonium bis(trifluoromethanesulfonyl)imide (MEBu3P]NTf2]) was used as solvent, affording the first example of a reaction rate superior to that in diisopropyl ether. |
| Keywords: | Ionic liquid Phosphonium salt Lipase Transesterification Rapid reaction |
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