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Shared as well as distinct roles of EHD proteins revealed by biochemical and functional comparisons in mammalian cells and <Emphasis Type="Italic">C. elegans</Emphasis> |
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| Authors: | Manju George GuoGuang Ying Mark A Rainey Aharon Solomon Pankit T Parikh Qingshen Gao Vimla Band " target="_blank">Hamid Band |
| Institution: | (1) Division of Molecular Oncology, Department of Medicine, Evanston Northwestern Healthcare Research Institute, Feinberg School of Medicine, Northwestern University, Evanston, Illinois, USA;(2) Division of Cancer Biology, Department of Medicine, Evanston Northwestern Healthcare Research Institute, Feinberg School of Medicine, Northwestern University, Evanston, Illinois, USA;(3) Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, Evanston, Illinois, USA;(4) Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Evanston, Illinois, USA |
| Abstract: | BackgroundThe four highly homologous human EHD proteins (EHD1-4) form a distinct subfamily of the Eps15 homology domain-containing protein family and are thought to regulate endocytic recycling. Certain members of this family have been studied in different cellular contexts; however, a lack of concurrent analyses of all four proteins has impeded an appreciation of their redundant versus distinct functions. |
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