Proteinases in the joint: clinical relevance of proteinases in joint destruction |
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Authors: | Yvonne Rengel Caroline Ospelt Steffen Gay |
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Institution: | Center of Experimental Rheumatology, University Hospital Zürich, Gloriastrasse, CH-8091 Zurich, Switzerland. |
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Abstract: | Proteinases are involved in essential steps in cartilage and bone homeostasis. Consequently, efforts have been made to establish
their potential role in the pathology of rheumatic conditions such as rheumatoid arthritis, osteoarthritis and spondyloarthritis.
Matrix metalloproteinases (MMPs) are sensitive markers of disease severity and response to treatment, and therefore they have
potential in the assessment of rheumatic diseases. Despite disappointing early results with synthetic inhibitors of MMPs,
there is still much scope for developing effective and safe MMPs inhibitors, and consequently to deliver new options to inhibit
joint destruction. |
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Keywords: | |
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