The OXR domain defines a conserved family of eukaryotic oxidation resistance proteins |
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| Authors: | Mathieu Durand Adrianne Kolpak Timothy Farrell Nathan A Elliott Wenlin Shao Myles Brown Michael R Volkert |
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| Institution: | 1.Department of Molecular Genetics and Microbiology,University of Massachusetts Medical School,Worcester,USA;2.Department of Chemistry and Biology,Université du Québec à Trois-Rivières,Trois-Rivières,Canada;3.Division of Molecular and Cellular Oncology, Department of Medical Oncology,Dana-Farber Cancer Institute,Boston,USA |
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| Abstract: | Background The NCOA7 gene product is an estrogen receptor associated protein that is highly similar to the human OXR1 gene product, which
functions in oxidation resistance. OXR genes are conserved among all sequenced eukaryotes from yeast to humans. In this study
we examine if NCOA7 has an oxidation resistance function similar to that demonstrated for OXR1. We also examine NCOA7 expression
in response to oxidative stress and its subcellular localization in human cells, comparing these properties with those of
OXR1. |
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