A systematic screen for genes expressed in definitive endoderm by Serial Analysis of Gene Expression (SAGE) |
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| Authors: | Juan Hou Anita M Charters Sam C Lee Yongjun Zhao Mona K Wu Steven JM Jones Marco A Marra Pamela A Hoodless |
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| Affiliation: | (1) Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, Canada;(2) Michael Smith Genome Sciences Centre, British Columbia Cancer Agency, Vancouver, Canada;(3) Department of Medical Genetics, University of British Columbia, Vancouver, Canada;(4) Terry Fox Laboratory, British Columbia Cancer Agency, 675 West 10th Avenue, V5Z 1L3 Vancouver, BC, Canada |
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| Abstract: | Background The embryonic definitive endoderm (DE) gives rise to organs of the gastrointestinal and respiratory tract including the liver, pancreas and epithelia of the lung and colon. Understanding how DE progenitor cells generate these tissues is critical to understanding the cause of visceral organ disorders and cancers, and will ultimately lead to novel therapies including tissue and organ regeneration. However, investigation into the molecular mechanisms of DE differentiation has been hindered by the lack of early DE-specific markers. |
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