Dissection of a metastatic gene expression signature into distinct components |
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| Authors: | Paul Roepman Erica de Koning Dik van Leenen Roel A de Weger J Alain Kummer Piet J Slootweg Frank CP Holstege |
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| Affiliation: | (1) Department of Physiological Chemistry, University Medical Center Utrecht, Universiteitsweg, Utrecht, the Netherlands;(2) Department of Pathology, University Medical Center Utrecht, Heidelberglaan, Utrecht, the Netherlands |
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| Abstract: | Background Metastasis, the process whereby cancer cells spread, is in part caused by an incompletely understood interplay between cancer cells and the surrounding stroma. Gene expression studies typically analyze samples containing tumor cells and stroma. Samples with less than 50% tumor cells are generally excluded, thereby reducing the number of patients that can benefit from clinically relevant signatures. |
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