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Comparative proteome analysis of human epithelial ovarian cancer |
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| Authors: | Jean-Philippe Gagné Chantal éthier Pierre Gagné Geneviève Mercier Marie-ève Bonicalzi Anne-Marie Mes-Masson Arnaud Droit Eric Winstall Maxim Isabelle and Guy G Poirier |
| Institution: | (1) Health and Environment Unit, Laval University Medical Research Center, CHUQ, Faculty of Medicine, Laval University, 2705, Boulevard Laurier, Ste-Foy, Qu?bec, G1V 4G2, Canada;(2) Proteomics Platform, Qu?bec Genomic Center, Laval University Medical Research Center, CHUQ, Faculty of Medicine, Laval University, 2705, Boulevard Laurier, Ste-Foy, Qu?bec, G1V 4G2, Canada;(3) Centre de recherche du Centre Hospitalier de l'Universit? de Montr?al, (CHUM)-H?pital Notre-Dame and Institut du cancer de Montr?al, 1560 rue Sherbrooke Est, Montr?al, Qu?bec, H2L 4M1, Canada;(4) Groupe Cycle Cellulaire, CNRS UMR6061 Universit? de Rennes 1, Universit? de Rennes 1, Facult? de M?decine, 2 Avenue du Pr L?on Bernard, CS 3417 Rennes cedex, France |
| Abstract: | BackgroundEpithelial ovarian cancer is a devastating disease associated with low survival prognosis mainly because of the lack of early detection markers and the asymptomatic nature of the cancer until late stage. Using two complementary proteomics approaches, a differential protein expression profile was carried out between low and highly transformed epithelial ovarian cancer cell lines which realistically mimic the phenotypic changes observed during evolution of a tumour metastasis. This investigation was aimed at a better understanding of the molecular mechanisms underlying differentiation, proliferation and neoplastic progression of ovarian cancer. |
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