A survey of orphan enzyme activities |
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| Authors: | Yannick Pouliot Peter D Karp |
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| Institution: | (1) Bioinformatics Research Group, Artificial Intelligence Center, SRI International, 333 Ravenswood Ave, Menlo Park, California 94025-3493, USA;(2) Lane Medical Library and Knowledge Management Center, Information Resources and Technology, Stanford University Medical Center, 300 Pasteur Drive, Stanford, CA 94305-5123, USA |
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| Abstract: | Background Using computational database searches, we have demonstrated previously that no gene sequences could be found for at least
36% of enzyme activities that have been assigned an Enzyme Commission number. Here we present a follow-up literature-based
survey involving a statistically significant sample of such "orphan" activities. The survey was intended to determine whether
sequences for these enzyme activities are truly unknown, or whether these sequences are absent from the public sequence databases
but can be found in the literature. |
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