水溶性三七总皂苷制备与表征

为提高三七总皂苷的水溶性及其制剂在体内的稳定性和生物利用度，运用喷雾干燥法对三七总皂苷进行超细化，利用正交试验分析得到喷雾干燥制备三七总皂苷超细粉的最佳条件并对其各项指标进行检测。经分析所得最佳制备条件为：进口温度为140℃、三七总皂苷的浓度为65 g·L^-1、进料流速为30 L·h^-1和空气脉冲为4。对三七总皂苷原粉和喷雾干燥所得超细粉进行了理化性质检测，SEM扫描结果显示超细粉形貌规则，激光粒度仪测得粒径为70.5 nm；红外光谱检测所得结果证实超细粉化学性质较原粉无明显改变，不影响其药性；通过DSC、X-Ray检测所得结果显示超细粉与原粉相比晶体结晶度有所改变说明其水溶性增加。

Preparation and Characterization of Water-soluble Panax Notoginsenosides

To improve the water-solubility, In vivo stability and bioavailability of Panax notoginsenosides(PNS), superfine PNS powder was carried on by the spray-drying process. In this paper, the optimal conditions for preparing superfine PNS powder by spray-drying process were obtained by using orthogonal experimental analysis and each index for superfine PNS powder was detected. After the orthogonal experimental analysis, the optimal preparation conditions were obtained as follows: Inlet temperature 140℃, concentration of PNS 65 g·L^-1, feeding flow 30 L·h^-1 and air pulse 4. The physicochemical properities of PNS original powder were examined. SEM result demonstrated that the morphology of the superfine PNS powder appears regular, the particle size is 70.5 nm as measured by laser particle size analyzer. The infrared spectrum examination result confirmed that the chemical property of the superfine PNS powder is similar to original powder. DSC and X-Ray examinations showed that the crsytal structure of the superfine PNS powder is different from PNS original powder, indicating the increase of water-solubility.