SIP1 Mediates Cell-Fate Decisions between Neuroectoderm and Mesendoderm in Human Pluripotent Stem Cells |
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| Authors: | Zhenzhi Chng Adrian Teo Roger A Pedersen Ludovic Vallier |
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| Institution: | 1. Laboratory for Regenerative Medicine, West Forvie Building, Robinson Way, University of Cambridge, Cambridge, CB2 0SZ, UK |
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| Abstract: |  Download : Download high-res image (184KB)Download : Download full-size imageHighlights? Smad-interacting protein 1 (SIP1) regulates hESC differentiation ? SIP1 upregulation promotes neuroectodermal differentiation ? SIP1 inhibits mesendodermal and endodermal differentiation ? SMAD2/3 and NANOG/OCT4/SOX2 cooperatively regulate SIP1 expression |
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