Xanthones and a benzophenone from the roots of Pentadesma butyracea and their antiproliferative activity |
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| Authors: | Hippolyte K. Wabo Haruhisa Kikuchi Yasuhiro Katou Pierre Tane Yoshiteru Oshima |
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| Affiliation: | 1. Department of Chemistry, University of Dschang, P.O. Box 67, Dschang, Cameroon;2. Graduate School of Pharmaceutical Sciences, Tohoku University, 6-3 Aoba, Aramaki, Aoba-ku, Sendai 980-8578, Japan |
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| Abstract: | A new xanthone, 3,4-dihydro-8,10,12-trihydroxy-2,2-dimethylpyrano[2,3-b]xanthen-11(2H)-one or butyraxanthone E (1), along with the known compounds 30-epi-cambogin (2), 1,7-dihydroxyxanthone (3) and 1,5-dihydroxyxanthone (4) were isolated from the roots of Pentadesma butyracea. Their structures were elucidated by spectroscopic means and comparison with published data. Their antiproliferative activities were evaluated against Drosophila S2 cells and two human cancer cell lines, THP-1 (leukemia) and HCT116 (colon cancer). Compounds 1 and 2 showed moderate antiproliferative activity against Drosophila S2 cells and the HCT116 cell line, respectively. Compound 2 was active against Drosophila S2 cells. |
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