A novel approach to estimate the German-wide incidence of testicular cancer |
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| Authors: | Andreas Stang Alexander Katalinic Klaus-Peter Dieckmann Ron Pritzkuleit Roland Stabenow |
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| Affiliation: | 1. Institute of Clinical Epidemiology, Medical Faculty, Martin-Luther-University of Halle-Wittenberg, Magdeburger Str. 8, 06097 Halle, Germany;2. Institute of Cancer Epidemiology at University of Luebeck, Beckergrube 43-47, 23552 Lübeck, Germany;3. Department of Urology, Albertinen-Hospital, Süntelstraße 11a, 22457 Hamburg, Germany;4. Common Cancer Registry of the Federal States of Berlin, Brandenburg, Mecklenburg-Vorpommern, Sachsen-Anhalt, and the Free States of Sachsen and Thüringen (GKR), Brodauer Str. 16-22, 12621 Berlin, Germany;1. Department of Pharmacology, Arizona Health Sciences Center, University of Arizona, Tucson, AZ, USA;2. Department of Anesthesiology, Arizona Health Sciences Center, University of Arizona, Tucson, AZ, USA;3. Departments of Anesthesia and Radiology, Boston Children’s Hospital, Harvard Medical School, Boston, MA, USA;1. Division of Epidemiology and Public Health, University of Nottingham, Nottingham NG5 1PB, UK;2. Derby Hospital NHS Foundation Trust, Derby DE22 3NE, UK;3. Edinburgh Cancer Centre, Western General Hospital, EH4 2JT, UK;4. School of Nursing, Midwifery and Social Work, Central Manchester NHS Foundation Trust, M13 9PL, UK;5. School of Primary & Social Care, London South Bank University, SE1 0AA, UK;6. St. James Hospital, Leeds Teaching Hospital, LS9 7TF, UK;1. Department of Epidemiology, College of Public Health, University of Nebraska Medical Center, Omaha, NE 68198-4395, U.S.A;2. Gharbiah Cancer Society, Tanta, Egypt;1. Department of Anesthesiology, Perioperative Care and Pain Medicine, New York, NY 10016, United States;2. Department of Neuroscience and Physiology, New York University School of Medicine, New York, NY 10016, United States;1. Evaluative Epidemiology, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Via Venzian 1, Milan, Italy;2. Escuela Andaluza de Salud Pública, Instituto de Investigación Biosanitaria ibs.G., Hospitales Universitarios de Granada/Universidad de Granada, 18080 Cuesta del Observatorio 4, Campus Universitario de Cartuja, Granada, Spain;3. CIBER de Epidemiología y Salud Pública (CIBERESP), Melchor Fernández Almagro 3-5, 28029 Madrid, Spain;4. Centre for Public Health, School of Medicine, Dentistry and Biomedical Science, Queen’s University Belfast 2012, University Road Belfast, BT7 1NN Northern Ireland, UK;5. Centro Nazionale di Epidemiologia, Sorveglianza e Promozione della Salute, Istituto Superiore di Sanità,Viale Regina Elena 299, Rome, Italy;6. Head and Neck Cancer Medical Oncology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Via Venzian 1, Milan, Italy;1. Children’s Haematology/Oncology Centre, Christchurch Hospital, Christchurch, New Zealand;2. National Child Cancer Network, Auckland, New Zealand;3. New Zealand Cancer Registry, Ministry of Health, Wellington, New Zealand;4. Starship Blood and Cancer Centre, Starship Children’s Hospital, Auckland, New Zealand;5. Department of Pathology and Laboratory Medicine, Auckland City Hospital, Auckland, New Zealand |
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| Abstract: | Background: Currently, only 7 out of 16 Federal States of Germany provide testicular cancer incidence rates with an estimated completeness of at least 90% which complicates the regional comparison of incidence rates. The aim of this study was to provide a novel approach to estimate the testicular cancer incidence in Germany by using nationwide hospitalization data. Methods: We used the nationwide hospitalization data (DRG statistics) of the years 2005–2006 including 16,6 million hospitalizations among men. We identified incident testicular cancer cases by the combination of a diagnosis of testicular cancer and an orchiectomy during the same hospitalization and estimated the age-specific and age-standardized (World Standard Population) incidence of testicular cancer across Federal States. We also analyzed available cancer registry data from 2005 to 2006. Results: A total of 8544 hospitalizations indicated incident testicular cancer cases in 2005–2006. The nationwide crude incidence rate of testicular cancer was 10,6 per 100.000 person-years. The ratio of the number of registered cases (cancer registry) to the estimated number of cases based on the hospitalization statistics ranged between 79% and 100%. There was only little variation of the age-standardized DRG-based incidence estimates across Federal States (range: 8,2–10,6 per 100.000 person-years). Discussion: We provided testicular cancer incidence estimates for each of the 16 Federal States of Germany based on hospitalization data for the first time. The low within-population incidence variability in Germany and high between-population incidence variability in Europe may indicate that ecologic factors play a causal role in the European variation of testicular cancer. |
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