In vitro antiprotozoal activity of alkaloids from Phaedranassa dubia (Amaryllidaceae) |
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| Authors: | Edison J. Osorio Strahil Berkov Reto Brun Carles Codina Francesc Viladomat Fabio Cabezas Jaume Bastida |
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| Affiliation: | 1. Grupo de Investigación en Sustancias Bioactivas, Facultad de Química Farmacéutica, Universidad de Antioquia, A.A. 1226, Medellín, Colombia;2. Departament de Productes Naturals, Facultat de Farmàcia, Universitat de Barcelona, Avn. Joan XXIII s/n, 08028 Barcelona, Spain;3. Parasite Chemotherapy, Swiss Tropical Institute, Socinstrasse 57, CH-4051 Basel, Switzerland;4. Departamento de Química, Grupo de Química de Compuestos Bioactivos, Universidad del Cauca, A.A. 304, Popayán, Colombia |
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| Abstract: | The bulbs of Phaedranassa dubia (Amaryllidaceae) were found to contain the novel compound phaedranamine, together with seven known alkaloids. The structure and stereochemistry of the alkaloids were determined by physical and spectroscopic methods. An in vitro screening against four different parasitic protozoa was carried out using the isolated compounds. The alkaloids ungeremine, pseudolycorine and haemanthamine showed good activity in in vitro assays against Trypanosoma brucei rhodesiense, T. cruzi and Plasmodium falciparum with IC50 values in the range of 3.66 μM or lower. |
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