| PRMT5在癌症中的研究进展 |
| |
| 引用本文： | 何伶靖,邹成,贺琴菊,冯宇晴,张定校. PRMT5在癌症中的研究进展[J]. 中国细胞生物学学报, 2021, 0(3): 662-674 |
| |
| 作者姓名： | 何伶靖 邹成 贺琴菊 冯宇晴 张定校 |
| |
| 作者单位： | 湖南大学生物学院 |
| |
| 基金项目： | 国家自然科学基金(批准号:81972418);中央高校基本科研业务费(批准号:531119200130)资助的课题。 |
| |
| 摘 要： | 蛋白质精氨酸甲基转移酶(protein arginine methyltransferases,PRMTs)是真核生物中常见的一种酶,可催化组蛋白和非组蛋白底物中的精氨酸残基发生甲基化.在人类的基因组中,PRMTs由9个基因编码.作为最主要的Ⅱ型精氨酸甲基转移酶,PRMT5是PRMT家族成员之一,参与了包括信号转导、转...
|
| 关 键 词： | 癌症 蛋白质精氨酸甲基转移酶 PRMT5 基因表达调控 小分子靶向治疗 |
Recent Advances of PRMT5 in Cancer |
| |
| HE Lingjing,ZOU Cheng,HE Qinju,FENG Yuqing,ZHANG Dingxiao. Recent Advances of PRMT5 in Cancer[J]. Chinese Journal of Cell Biology, 2021, 0(3): 662-674 |
| |
| Authors: | HE Lingjing ZOU Cheng HE Qinju FENG Yuqing ZHANG Dingxiao |
| |
| Affiliation: | (Center of Tumorigenesis and Molecular Medicine,College of Biology,Hunan University,Changsha 410082,China) |
| |
| Abstract: | Protein arginine methylation is one of the most abundant and evolutionarily conserved post-translational modifications catalyzed by the PRMTs(protein arginine methyltransferases).PRMTs,encoded by nine genes in the human genome,can methylate histone and nonhistone proteins.As the main type II arginine methyltransferase,PRMT5 has been implicated in the control of many cellular processes such as cell cycle progression,signal transduction,gene expression regulation,RNA splicing and DNA-damage response.Overexpression of PRMT5 is frequently found in numerous human cancers with evidence indicative of an oncogene-like function.Here,an update on the recent advances of PRMT5 in cancer research is provided and the promise of targeting PRMT5 by small molecular inhibitors is discussed for treating aggressive human cancers. |
| |
| Keywords: | cancer protein arginine methyltransferases PRMT5 gene expression regulation targeted cancer therapy with small molecules |
| 本文献已被 维普 等数据库收录！ |
|
