Benzochromenes from the roots of Bourreria pulchra |
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| Authors: | Gilda J. Erosa-Rejón Alejandro Yam-Puc Manuel J. Chan-Bacab Alberto Giménez-Turbax Efraín Salamanca Luis M. Peña-Rodríguez Olov Sterner |
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| Affiliation: | 1. Division of Organic Chemistry, Lund University, PO Box 124, SE-22100 Lund, Sweden;2. Laboratorio de Química Orgánica, Unidad de Biotecnología, Centro de Investigación Científica de Yucatán, Calle 43 #130 Col., Chuburná de Hidalgo, C.P. 97200 Mérida, Yucatán, Mexico;3. Departamento de Microbiología Ambiental y Biotecnología, Universidad Autónoma de Campeche. Av. Agustín Melgar s/n, C.P. 24030 Campeche, Mexico;4. Instituto de Investigaciones Farmaco Bioquímicas C.P. 20606, Universidad Mayor de San Andrés, La Paz, Bolivia |
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| Abstract: | Two new benzochromenes, (6,6-dimethyl-2-methoxy-6H-benzo[c]chromen-9-yl)methanol (1), and 2-methoxy-6,6-dimethyl-6H-benzo[c]chromen-9-carbaldehyde (2), together with several already known metabolites, were isolated from the root extract of Bourreria pulchra (Boraginaceae). The structures of 1 and 2 were established on the basis of their spectroscopic data. Both were assayed for in vitro antiprotozoan activity, and especially 1 was found to possess significant activity against Leishmania mexicana and Trypanosoma cruzi parasites (IC50 4.6 μg/mL and 7.5 μg/mL, respectively). |
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