Sesquiterpenes from Xylaria sp., an endophytic fungus associated with Piper aduncum (Piperaceae) |
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| Authors: | Geraldo H Silva Camila M de Oliveira Helder L Teles Patrícia M Pauletti Ian Castro-Gamboa Dulce HS Silva Vanderlan S Bolzani Maria CM Young Claudio M Costa-Neto Ludwig H Pfenning Roberto GS Berlinck Angela R Araujo |
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| Institution: | 1. Universidade Federal de Sergipe, Departamento de Química, Itabaiana, 49500-000 Se, Brazil;2. Universidade Federal do Mato Grosso, Departamento de Ciências Biológicas, Rondonópolis, 78735-901, MT, Brazil;3. NuBBE - Núcleo de Bioensaios, Biossíntese e Ecofisiologia de Produtos Naturais, Universidade Estadual Paulista, Instituto de Química, 14800-900 Araraquara, SP, Brazil;4. Universidade de Franca, 13570-050 Franca, São Paulo, Brazil;5. Secção de Fisiologia e Bioquímica de Plantas, Instituto de Botânica, 01061-970 São Paulo, SP, Brazil;6. Departamento de Bioquímica e Imunologia, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, 14049-900 Ribeirão Preto, SP, Brazil;7. Universidade Federal de Lavras, Departamento de Fitopatologia, 37200-000 Lavras, MG, Brazil;8. Instituto de Química de São Carlos, Universidade de São Paulo, 13560-970 CEP São Carlos, SP, Brazil |
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| Abstract: | Two new presilphiperfolane sesquiterpenes, 1 and 2, were isolated from the ethyl acetate extract of Xylaria sp., obtained from the leaves of Piper aduncum, along with two known eremophilane sesquiterpenes, phaseolinone (3) and phomenone (4). Chemical structures of 1 and 2 were established by analysis of spectroscopic data. The four compounds were tested in vitro for antifungal and cytotoxicity activities using CHO (Chinese hamster ovary). Compounds 1 and 2 did not show any antifungal and cytotoxic activity. Compounds 3 and 4 displayed moderate cytotoxic activities, as well as 4 antifungal activity. |
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