Perivascular Nitric Oxide Activates Notch Signaling and Promotes Stem-like Character in PDGF-Induced Glioma Cells期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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Perivascular Nitric Oxide Activates Notch Signaling and Promotes Stem-like Character in PDGF-Induced Glioma Cells

Authors:	Nikki Charles Tatsuya Ozawa Massimo Squatrito Anne-Marie Bleau Cameron W Brennan Dolores Hambardzumyan Eric C Holland

Institution:	1. Department of Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA;2. Brain Tumor Center, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA;3. Department of Neurosurgery and Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA

Abstract:	Download : Download high-res image (229KB) Download : Download full-size image Highlights? Perivascular niche nitric oxide activates Notch in PDGF-induced gliomas ? Notch signaling drives tumor stem-like characteristics and reduces survival ? Loss of eNOS activity decreases tumor stem-like characteristics ? Suppressing eNOS activity prolongs survival in glioma-bearing mice

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