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ESCs Require PRC2 to Direct the Successful Reprogramming of Differentiated Cells toward Pluripotency

Authors:	Carlos F Pereira Francesco M Piccolo Tomomi Tsubouchi Stephan Sauer Natalie K Ryan Ludovica Bruno David Landeira Joana Santos Ana Banito Jesus Gil Haruhiko Koseki Matthias Merkenschlager Amanda G Fisher

Institution:	1. Lymphocyte Development Group, MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK;2. Cell Proliferation Group, MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK;3. Department of Developmental Genetics, RIKEN Research Center for Allergy and Immunology, RIKEN Yokohama Institute, Yokohama, Japan

Abstract:	Download : Download high-res image (167KB) Download : Download full-size image Highlights? Mouse pluripotent cells reprogram human B cells in heterokaryons ? ESCs lacking PRC1 or PRC2 cannot successfully reprogram ? Failure of PRC1/2-deficient ESCs to reprogram is functionally dominant ? PRC1/2 play a critical role in the chromatin reorganization required for reprogramming

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