Two new diterpenoids from Plectranthus species |
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| Authors: | Maria Fátima Simões Patrícia Rijo Aida Duarte Diana Barbosa Diogo Matias Joana Delgado Nádia Cirilo Benjamín Rodríguez |
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| Affiliation: | 1. Faculdade de Farmácia da Universidade de Lisboa, iMed.UL, Av. Prof. Gama Pinto, 1649-003 Lisboa, Portugal;2. Instituto de Química Orgánica, CSIC, Juan de la Cierva 3, E-28006 Madrid, Spain |
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| Abstract: | Two new diterpenoids, ent-7α-acetoxy-15-beyeren-18-oic acid and (13S,15S)-6β,7α,12α,19-tetrahydroxy-13β,16-cyclo-8-abietene-11,14-dione, have been isolated from Plectranthus saccatus and Plectranthus porcatus, respectively, and their structures were established by 1D and 2D NMR spectroscopic studies. The new diterpenes showed no activity against Gram-negative bacteria and Candida albicans (yeast strain). Among Gram-positive bacteria, the lower MIC value was 62.50 μg/ml for the abietane derivative against Staphylococcus aureus ATCC 6538. |
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