Conserved and Divergent Roles of FGF Signaling in Mouse Epiblast Stem Cells and Human Embryonic Stem Cells期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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Conserved and Divergent Roles of FGF Signaling in Mouse Epiblast Stem Cells and Human Embryonic Stem Cells

Authors:	Boris Greber Guangming Wu Christof Bernemann Jin Young Joo Dong Wook Han Kinarm Ko Natalia Tapia Davood Sabour Jared Sterneckert Paul Tesar Hans R Schöler

Institution:	1. Department of Cell and Developmental Biology, Max Planck Institute for Molecular Biomedicine, Röntgenstraße 20, D-48149 Münster, Germany;2. Department of Genetics, Center for Stem Cell and Regenerative Medicine, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA;3. Medical Faculty, University of Münster, Domagkstr. 3, D-48149 Münster, Germany

Abstract:	Download : Download high-res image (158KB) Download : Download full-size image Highlights? Nanog is a direct target of Activin and SMAD2/3 but not FGF-ERK in EpiSCs ? FGF signaling inhibits neuroectodermal commitment of EpiSCs and hESCs ? FGF inhibition relieves Klf2 repression and reverts EpiSCs to an ESC-like state ? mESCs transition to an EpiSC-like state with LIF inhibition and FGF activation

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