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Sprouty1 Regulates Reversible Quiescence of a Self-Renewing Adult Muscle Stem Cell Pool during Regeneration
Authors:Kelly L Shea  Wanyi Xiang  Vincent S LaPorta  Jonathan D Licht  Charles Keller  M Albert Basson  Andrew S Brack
Institution:1. Massachusetts General Hospital, Center of Regenerative Medicine, Harvard University, Boston, MA 02114, USA;2. Department of Orthopedic Surgery, Massachusetts General Hospital, Boston, MA 02114, USA;3. Division of Hematology/Oncology, Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA;4. Department of Cellular & Structural Biology, The University of Texas Health Science Center, San Antonio, TX 78229, USA;5. Department of Craniofacial Development, King''s College London, Guy''s Campus, London SE1 9RT, UK
Abstract:
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  • Highlights? Pax7+ skeletal satellite cells regenerate muscle in their endogenous environment ? Quiescent satellite cells express the RTK inhibitor Spry1 ? Spry1 is needed for satellite cells to return to quiescence after muscle injury ? Deletion of Spry1 in satellite cells depletes the muscle stem cell pool
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