Intake of dietary fats and colorectal cancer risk: Prospective findings from the UK Dietary Cohort Consortium |
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| Authors: | Christina C. Dahm Ruth H. Keogh Marleen A.H. Lentjes Elizabeth A. Spencer Tim J. Key Darren C. Greenwood Janet E. Cade Victoria J. Burley Martin J. Shipley Eric J. Brunner Alison M. Stephen Gita Mishra Diana Kuh Ian S. Fentiman Ian R. White Robert Luben Kay Tee Khaw Sheila A. Rodwell |
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| Affiliation: | 1. Medical Research Council Centre for Nutritional Epidemiology in Cancer Prevention and Survival, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, United Kingdom;2. MRC Biostatistics Unit, Institute of Public Health, University of Cambridge, Cambridge CB2 0SR, United Kingdom;3. Cancer Epidemiology Unit, University of Oxford, Oxford OX3 7LF, United Kingdom;4. Centre for Epidemiology & Biostatistics, Level 8, Worsley Building, University of Leeds, Leeds LS2 9JT, United Kingdom;5. Department of Epidemiology and Public Health, University College London, London WC1E 6BT, United Kingdom;6. MRC Human Nutrition Research, Elsie Widdowson Laboratory, Cambridge CB1 9NL, United Kingdom;7. MRC Unit for Lifelong Health and Ageing, Department of Epidemiology and Public Health, University College London, 33 Bedford Place, London WC1B 5JU, United Kingdom;8. Academic Oncology Unit, Guy''s Hospital, London SE1 9RT, United Kingdom;9. Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, United Kingdom;1. Department of Epidemiology, IRCCS – Istituto di Ricerche Farmacologiche “Mario Negri”, Via Giuseppe La Masa 19, 20156 Milan, Italy;2. Department of Clinical Sciences and Community Health, Università degli Studi di Milano, Milan, Italy;3. Unity of Medical Statistics, Biometry and Bioinformatics, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy;4. Unit of Epidemiology and Biostatistics, Centro di Riferimento Oncologico, IRCCS, Aviano, PN, Italy;5. Registro Tumori della Romagna, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST), Meldola, FO, Italy;6. Unit of Epidemiology, Istituto Tumori “Fondazione Pascale”, Naples, Italy;7. International Agency for Research on Cancer, Lyon, France;1. Institute of Health and Wellbeing, University of Glasgow, 1 Lilybank Gardens, Glasgow, UK;2. Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK;1. Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA;2. Intestinal Microbiology Research Group, Department of Molecular Toxicology, German Institute of Human Nutrition, Potsdam-Rehbruecke, Nuthetal, Germany;1. Bioinformatics and Medical Informatics Research Center, San Diego State University, San Diego 92182, USA;2. Institute of Bioinformatics and Biotechnology, Savitribai Phule Pune University, Pune 411007, India |
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| Abstract: | Introduction: Epidemiologic evidence for an association between colorectal cancer (CRC) risk and total dietary fat, saturated fat (SF), monounsaturated fat (MUFA) and polyunsaturated fat (PUFA) is inconsistent. Previous studies have used food frequency questionnaires (FFQ) to assess diet, but data from food diaries may be less prone to severe measurement error than data from FFQ. Methods: We conducted a case–control study nested within seven prospective UK cohort studies, comprising 579 cases of incident CRC and 1996 matched controls. Standardized dietary data from 4- to 7-day food diaries and from FFQ were used to estimate odds ratios for CRC risk associated with intake of fat and subtypes of fat using conditional logistic regression. We also calculated multivariate measurement error corrected odds ratios for CRC using repeated food diary measurements. Results: We observed no associations between intakes of total dietary fat or types of fat and CRC risk, irrespective of whether dietary data were obtained using food diaries or FFQ. Conclusion: Our results do not support the hypothesis that intakes of total dietary fat, SF, MUFA or PUFA are linked to risk of CRC. |
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