Cucurbitacins from Bryonia cretica |
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Authors: | Amal A. Sallam Yukio Hitotsuyanagi El-Sayed S. Mansour Atallah F. Ahmed Sahar Gedara Haruhiko Fukaya Koichi Takeya |
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Affiliation: | 1. Pharmacognosy Department, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt;2. School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan |
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Abstract: | From the roots of Bryonia cretica L. two new cucurbitacins, isocucurbitacins G (1) and H (2), along with three known cucrbitacins, cucurbitacins G (3), H (4), and J (5) were isolated. The structures of 1 and 2 were determined on the basis of 1D and 2D NMR spectroscopic analysis and X-ray crystallography. The relative stereochemistries of the side chains of 3–5 were also established by comparison of their NMR data and X-ray crystallography. |
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