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The oxidation of endogenous ascorbic acid during histamine secretion by rat peritoneal mast cells |
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| Authors: | Mary J. Ortner |
| Affiliation: | 1. Laboratory for Histochemistry and Cytochemistry, Sylvius Laboratories, State university Leiden, 2300 RA Leiden, The Netherlands;2. Section for Medical Enzymology and Molecular Biology, Laboratory of Biochemistry, University of Amsterdam, Amsterdam, The Netherlands |
| Abstract: | Endogenous ascorbic acid is oxidized to the free radical species by rat mast cells during histamine secretion. This antioxidant may function as a radical scavenger of Superoxide and other membrane-damaging radicals known to be liberated by this process. The high levels of ascorbic acid in mast cells may, therefore, function to protect the cell membrane from oxidative damage and thereby promote cell survival after an extensive secretory response. |
| Keywords: | Present address: Department of Biology 16-619 Massachusetts Institute of Technology 77 Massachusetts Avenue Cambridge MA 02139 USA. To whom offprint requests should be addressed. |
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