Antigen receptor-mediated calcium signals in B cells as revealed by confocal fluorescence microscopy |
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| Authors: | H Yamada J Mizuguchi M Nakanishi |
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| Affiliation: | Faculty of Pharmaceutical Sciences, Nagoya City University, Japan. |
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| Abstract: | A confocal fluorescence microscope was used to study the antigen receptor-mediated calcium signals in B cells. Anti-IgD binding to B lymphoma cells (BAL17) increased the intracellular calcium concentration with short lag times. Confocal fluorescence images of the fluo-3-loaded BAL17 cells showed that the intracellular calcium ion concentrations increased non-homogeneously, suggesting that the calcium signals transferred not only to the cytoplasm but also to the nucleus. |
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