Association between insomnia symptoms and hemoglobin A1c level in Japanese men |
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Authors: | Kachi Yuko Nakao Mutsuhiro Takeuchi Takeaki Yano Eiji |
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Affiliation: | Department of Hygiene and Public Health, School of Medicine, Teikyo University, Tokyo, Japan. katti@orange.zero.jp |
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Abstract: |
BackgroundThe evidence for an association between insomnia symptoms and blood hemoglobin A1c (HbA1c) level has been limited and inconclusive. The aim of this study was to assess whether each symptom of initial, middle, and terminal insomnia influences HbA1c level in Japanese men.MethodsThis cross-sectional study examined 1,022 male workers aged 22–69 years with no history of diabetes at a Japanese company''s annual health check-up in April 2010. High HbA1c was defined as a blood level of HbA1c ≥6.0%. Three types of insomnia symptoms (i.e., difficulty in initiating sleep, difficulty in maintaining sleep, and early morning awakening) from the previous month were assessed by 3 responses (i.e., lasting more than 2 weeks, sometimes, and seldom or never [reference group]).ResultsThe overall prevalence of high HbA1c was 5.2%. High HbA1c was positively and linearly associated with both difficulty in maintaining sleep (P for trend = .002) and early morning awakening (P for trend = .007). More specifically, after adjusting for potential confounding factors, high HbA1c was significantly associated with difficulty in maintaining sleep lasting more than 2 weeks (adjusted odds ratio, 6.79 [95% confidence interval, 1.86–24.85]) or sometimes (2.33 [1.19–4.55]). High HbA1c was also significantly associated with early morning awakening lasting more than 2 weeks (3.96 [1.24–12.59]).ConclusionInsomnia symptoms, particularly difficulty in maintaining sleep and early morning awakening, were found to have a close association with high HbA1c in a dose-response relationship. |
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