Mapping by admixture linkage disequilibrium: advances, limitations and guidelines |
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Authors: | Smith Michael W O'Brien Stephen J |
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Affiliation: | Laboratory of Genomic Diversity, National Cancer Institute, Frederick, Maryland 21702, USA. smithm@ncifcrf.gov |
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Abstract: | Mapping by admixture linkage disequilibrium (MALD) is a theoretically powerful, although unproven, approach to mapping genetic variants that are involved in human disease. MALD takes advantage of long-range haplotypes that are generated by gene flow among recently admixed ethnic groups, such as African-Americans and Latinos. Under ideal circumstances, MALD will have more power to detect some genetic variants than other types of genome-wide association study that are carried out among more ethnically homogeneous populations. It will also require 200-500 times fewer markers, providing a significant economic advantage. The MALD approach is now being applied, with results expected in the near future. |
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