MONOAMINES AS POSSIBLE MEDIATORS IN THE REGULATION OF FAST AXOPLASMIC FLOW |
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| Authors: | R. J. Boegman P. L. Wood |
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| Affiliation: | Department of Pharmacology, Queen's University, Kingston, Ontario, Canada |
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| Abstract: | —The effect of drugs which have been shown to alter monoamines in the CNS on the rate of fast axoplasmic flow of [3H]leucine labelled material in the rat sciatic nerve was examined. Drugs which deplete monoamines led to a decrease while those which increase the level of monoamines led to an increase in the rate of fast axoplasmic flow. Monoaminergic drugs were also found to alter the amount of [3H]leucine incorporated into spinal cord. |
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