New steroid glycosides from the starfish Fromia milleporella |
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| Authors: | E V Levina A I Kalinovsky V S Levin |
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| Institution: | (1) Pacific Institute of Bioorganic Chemistry, Far East Division, Russian Academy of Sciences, pr. 100-letiya Vladivostoka 159, Vladivostok, 690022, Russia |
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| Abstract: | Two new steroid glycosides from the starfish Fromia milleporella collected in the Seychelles were isolated and characterized: milleporoside A, (20R, 24R)-29-O-3-O-methyl-β-D-xylopyranosyl-(1→4)-3-O-methyl-β-D-xylopyranosyl]-24-ethyl-5α-cholestane-3β,4β,6α,8,15β,16β,29-heptaol, and milleporoside B, (20R, 24R)-(22E)-28-O-3-O-methyl-β-D-xylopyranosyl-(1→4)-3-O-methyl-β-D-xylopyranosyl]-24-methyl-5α-cholest-22-ene-3β,4β,6α,8,15β,16β,28-heptaol. The structures of the glycosides were determined from their spectra and a comparison with spectral characteristics of known compounds. These compounds exhibit a moderate cytostatic activity toward the embryos of the sea urchin Strongylocentrotus intermedius. |
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| Keywords: | glycosides MALDI TOF mass spectra NMR spectra polyhydroxysteroids starfish Fromia milleporella |
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